Eins by Gene Ontology assignment was performed using DAVID v6.7 (28, 29). Proteins were uploaded into the DAVID functional annotation tool and compared with the human genome background. Enriched pathways and Gene Ontology FAT terms with a minimum of twofold enrichment and a Fisher's Exact test p value 0.05 were considered and the top Gene Ontology terms that are shared between the extracapsular an